A groundbreaking study from the University of Georgia has taken a major step toward treating male infertility, which is rising globally. For the first time, scientists have created functional sperm cells from primate embryonic stem cells in a laboratory setting.
The research, published in Fertility and Sterility Science, used embryonic stem cells from rhesus macaque monkeys to generate immature sperm cells called round spermatids. These lab-grown spermatids successfully fertilized macaque eggs, marking a key milestone in reproductive science.
“This is the first step that shows this technology is potentially translatable,” said Charles Easley, one of the lead researchers. “We’re using a species that’s more relevant to humans, and we’re having success in making healthy embryos.”
Previous studies have produced sperm-like cells from mouse stem cells. However, mouse reproductive systems differ significantly from humans. The use of rhesus macaques, which share similar reproductive traits with humans, makes this study a crucial advance.
The team used a novel method to turn the stem cells into round spermatids. Just like natural immature spermatids, these lab-grown cells needed additional factors to activate the egg and allow for embryo development.
Next, the team plans to implant the embryos into surrogate rhesus macaques later this year. If the embryos develop into healthy offspring, the researchers aim to repeat the process using skin-derived stem cells from macaques.
This research could one day lead to new stem cell-based treatments for men who are unable to produce sperm, offering hope to millions affected by infertility.
Related topics:
